Ai J, Zhang H, Zhang Q, Zhang Y, Lin K, Fu Z, et al. Up to 10 percent of people who have COVID experience side effects" such as difficulty thinking, pain, tiredness, loss of taste and depression. Factors that influence the concentration of neutralizing antibodies and cellular responses were analyzed using a multivariate linear regression model, which could be set on one of the classified variances as a reference to calculate the B value (18). B pos, B Neg Blood Type Explained - Red Cross Blood Second, the reported adverse events could also have been underestimated due to the small number of participants and short observation period. J&J vaccine blood clot: Cause of rare side effect in COVID vaccines? There's no known connection between blood types and side effects from COVID-19 vaccines. Immunol. I don't think that having Type A or Type B is the problemit's just that they don't have Type O," says Mark Udden, MD, professor of hematology and oncology at Baylor College of Medicine in Houston. Furthermore, based on the study of Lusting etal. Eur J Med Res. Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). According to a CDC study which analyzed the first month of vaccinations, more than 79% of side effects were reported by women, even though women only accounted for 60% of vaccinations given.. N Engl J Med (2020) 383:201829. We only observed a trend of decreasing neutralizing antibodies after vaccination over time. Parums DV. Microbiol Spectr (2022) 10:e0118121. Does Large Study Slam Door on Blood Type-COVID Link? Hum Vaccin Immunother (2022) 18:2078634. doi:10.1080/21645515.2022.2078634, 9. Copyright 2023 Yuan, Xu, Ma, Chen, Wang, Wang, Jing, Zhang, Wang, Yan, Zhang, Zhao and Li. After adjusting for age, sex, occupation, blood type, interval between doses of vaccination, vaccination duration, and BMI, the highest geometric mean concentration (GMC) of neutralizing antibodies was 53.1 IU/mL in the same-manufacturer vaccination group at 1530 days, which was slightly but significantly higher than the 44.6 IU/mL found in the mixed-manufacturer vaccination group (p < 0.001) (Table2; Figure2B). Possible Side Effects After Getting a COVID-19 Vaccine | CDC In conclusion, safety concerns against SARS-CoV-2 vaccines are backed by an increasing number of studies reporting neurological side effects. Research is still finding clues about who's more susceptible and why. In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. The studies involving human participants were reviewed and approved by the ethics committee of Henan Provincial Peoples Hospital. Zhonghua Jie He He Hu Xi Za Zhi (2021) 44:49296. Blood type may influence other infections, as well. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. It's normal to experience side effects after the vaccine. Molly Walker, Associate Editor, MedPage Today Disclaimer. Anderson disclosed no relevant relationships with industry. Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. If you are hesitant because of the possibility of COVID vaccine side effects, the good news is, the risk of a severe reaction is low andDr. Based on the Chinese COVID-19 inactivated vaccine shot procedure (38 weeks), we divided the interval between two doses of the vaccination for the participants into two groups: 2140 and >40 days. In both intervention and control groups, the positive rate of neutralizing IgG antibodies specific to the SARS-CoV-2 RBD slowly increased to 84.1% from 1 to 14 days, peaked at 97.7% from 60 to 90 days, and then slowly decreased and remained at 82.9% from 180 to 240 days after the second vaccination. *Correspondence: Yi Li, liyilebmed@henu.edu.cn, These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all Brand of vaccine administered (Moderna or Pfizer-BioNTech) and the change in average blood glucose, peak blood glucose, and percentage of time spent in normal range as well as above average range of blood glucose level following vaccine administration will be assessed. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. In this study, a higher frequency of adverse events reported by participants in the mixed-manufacturer vaccination group. Lancet Respir Med (2021) 9:9991009. COVID-19 vaccine side effects causing worry for some people BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: A prospective, single-centre, longitudinal cohort study in health-care workers. In both groups, most of the adverse events were mild (n = 25, 81.1%) or moderate (n = 6, 18.9%) and self-limited. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. She is a 2020 J2 Achievement Award winner for her COVID-19 coverage. Safety of COVID-19 Vaccines Some people have no side effects. There have been multiple studies on blood types and COVID-19 risk. Participants in the mixed-manufacturer vaccination group, those with an interval of >40 days between doses of vaccination, and workers produced lower levels of IL-6 than those in the same-manufacturer vaccination group, those with an interval of <40 days between doses of vaccination, and medical staff (B = 0.01, 95% CI 0.014 to 0.003, p = 0.003, B = 0.44, 95% CI 0.8 to 0.1, p = 0.019, and B = 1.5, 95% CI 2.1 to 0.9, p < 0.001, respectively; Table6; Figures3FH). The number of participants was relatively small, and at the time of the clinical study design, the administrators did not advocate the administration of vaccines from different manufacturers for separate doses. doi:10.1001/jama.2021.19499, 11. All rights reserved. The most common adverse effect was fatigue (n = 4), followed by fever (n = 2), injection site pain (n = 4), malaise (n = 4), rash (n = 4), and pruritus (n = 3). All analyses, including linear regression, linear mixed models, and adverse effect analysis, were conducted using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) and plotted using Prism 8.0. Finally, individuals with certain occupations, including workers, especially older individuals and men, had low levels of antibodies and had weakened cellular immune responses following the second dose compared to their counterparts, suggesting that a longer gap between vaccine doses, which is a strategy in effect in some countries, should be re-evaluated, especially for more susceptible populations. Based on their age, we divided the participants into three groups, namely, 1830, 3150, and >50 years old. The effects of blood group types on the risk of COVID-19 - PubMed COVID-19: Vaccine safety and side effects - Canada.ca Cytokine levels and lymphocyte subset counts were measured using flow cytometry (Beamcyte-1026; Changzhou Beamdiag Co., Ltd., Changzhou, China). In conclusion, this study is the first to evaluate robust humoral and cellular immune responses at 240 days in 595 participants after a second dose of inactivated vaccine in individuals primed with the first dose. Safety and reactogenicity of a liquid formulation of human rotavirus vaccine (porcine circovirus-free): A phase III, observer-blind, randomized, multi-country study. According to the manufacturers instructions, values > 100 IU/mL were considered as 100 IU/mL. One study of over 3,000 people who got a COVID-19 vaccine did not find any increased side effects or other issues among people with different blood types. COVID Vaccine Side Effects: Here's Why Some People Suffer Severe Side Blood type O seems to have the lowest risk. Antibody responses to BNT162b2 vaccination in Japan: Monitoring vaccine efficacy by measuring IgG antibodies against the receptor-binding domain of SARS-CoV-2. The Link Between Blood Type and COVID-19 Risk - Health Researchers in China first shared this idea in March 2020, and the findings were echoed by a paper out of Columbia University a month later. COVID vaccines and safety: what the research says. Serious side effects. Coronavirus Vaccine Side Effects by Age - Business Insider The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Since both of those types are fairly rare, the Red Cross works hard to . Prospective cohort of Chinese individuals immunized with the inactivated vaccine and serological assays. COVID-19 Vaccination - Centers for Disease Control and Prevention Wong MCS, Wong ELY, Huang J, Cheung AWL, Law K, Chong MKC, et al. Furthermore, this study was the first to explore the association between the blood type of participants and humoral and cellular immune responses within 240 days after the administration of a Chinese inactivated vaccine. Blood type is actually a pretty weak player, Dr. Udden says. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. Therefore, the objective of this study was to evaluate the cellular immune responses and neutralizing antibody kinetics of homologous and heterologous administrations of an inactivated coronavirus disease 2019 (COVID-19) vaccine 240 days after the second vaccination. Once a vaccine goes into your arm, your blood flow increases and immune cells rush to the scene. Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. In this study, the older population produced lower levels of neutralizing antibodies, IFN-, B-lymphocytes, and IL-6, similar to that in previous studies (3, 25). Except for blood type, all demographic and baseline characteristics were balanced between the intervention and control groups (Table1). 8600 Rockville Pike By February 21, 2021, more than 46 million persons received at least 1 dose of an mRNA-based COVID-19 vaccine. Negative blood types are also somewhat protected from the virus. Unfortunately, this is a much more rare blood type. Glob Health Res Policy (2022) 7:21. doi:10.1186/s41256-022-00255-1, 12. 30. BMI, body mass index; LSMD, least-square mean difference. As of Dec. 24, there were more than 700,000 reports of adverse events . These Type A antibodies might make it more difficult for SARS-CoV-2 to attach to its receptor in Type O blood and multiply in the body, he explains. We constantly strive to provide you with the best information possible. (D) Kinetics of B-lymphocyte count according to age. The results were notable: Adjusting for demographics and co-morbidities, the risk for a COVID-19 diagnosis was 12 percent lower for people with type O blood and the risk for severe COVID-19 or death was 13 percent lower, compared to those with A, AB, or B blood types. The signs are trouble breathing, swelling of the face and throat, rash, and low blood pressure. This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. Our findings could provide evidence for an appropriate vaccination strategy against COVID-19. Then, a study published in the New England Journal of Medicine confirmed the idea with a peer-reviewed study: Folks with Type A blood were 45 percent more likely to become infected with Covid than those with other blood types, while those with Type O were 35 percent less likely. Opens in a new tab or window, Share on LinkedIn. Covid vaccine side effects: CDC says these are the most common - CNBC Most side effects are mild and normally last only a day or two. doi:10.3760/cma.j.cn112147-20200928-01013, 5. The full eligibility criteria were provided in the volunteer recruitment notification distributed through social networks, including WeChat groups. It's more the everyday things: According to Harvard Medical School physician Abraar Karan, the primary side effects of the COVID-19 vaccine are those pesky, flu-like, symptoms you're used. The .gov means its official. Patients were aged 25 to 63 years, had PNH granulocyte clones of 80%, and had not received transfusions in the past year. This study had limitations. Keywords: The severity of the COVID-19 disease Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). April 5, 2021. According to Pfizer, about 3.8% of their clinical trial participants experienced fatigue as a side effect and 2% got a headache. The early response observed 30 days after the second dose showed a boost effect linked to the same manufacturers scheme. Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). It may affect your immune systems strength or your inflammatory response to the infection. The log2-transformed level of neutralizing antibodies was used as the independent variable. Researchers have been talking about blood type and COVID-19 susceptibility for months. COVID-19 Vaccine Side Effects: What To Expect - Health Coronavirus & COVID-19 Overview: Symptoms, Risks, Prevention - WebMD Both primary and safety analyses included all participants who received two doses of the inactivated vaccine and had suffered local and systemic adverse events for 30 consecutive days after vaccination. Vaccine Side Effects: What Are They? What If I Don't Have Any - NPR Nous, Yahoo, faisons partie de la famille de marques Yahoo. This content includes information from experts in their field and is fact-checked to ensure accuracy. A review of neurological side effects of COVID-19 vaccination. var xhr = new XMLHttpRequest(); There were no differences in the positive rate of neutralizing antibodies between the groups throughout the observation period (p = 0.891; Figure2A). In rare cases, coronavirus vaccines may cause Long Covid-like symptoms "Rh blood type was protective against SARS-CoV-2 infection, especially for those who were O-negative," they wrote. Because these detected records included missing data for neutralizing antibodies and cellular immune responses, we used mixed linear models that can handle unequal numbers of repeated observations for individuals when there were random missing data. Moderna says 9.7% of their participants felt fatigued and 4.5% got . Blood type and COVID-19? | MIT Medical Characteristics of humoral and cellular responses to coronavirus Published by John Wiley & Sons Ltd. Wheatley AK, Juno JA, Wang JJ, Selva KJ, Reynaldi A, Tan HX, et al. 2021 Sep 2;17(9):2957-2958. doi: 10.1080/21645515.2021.1922061. Source Reference: Anderson JL, et al "Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population" JAMA Netw Open 2021; DOI: 10.1001/jamanetworkopen.2021.7429. COVID-19 and the Blood | NHLBI, NIH doi:10.6061/clinics/2021/e3286 Introduction: In China, the long-term immunogenicity and adverse effects of inactivated vaccines produced by different or the same manufacturer remain unclear. Future Sci OA (2021) 7:FSO735. Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines - JAMA Share on Facebook. In China, the latter three have been approved and are produced by eight manufacturers. "Given the large and prospective nature of our study and its strongly null results, we believe that important associations of SARS-CoV-2 and COVID-19 with ABO groups are unlikely and will not be useful factors associated with disease susceptibility or severity on either an individual or population level for similar environments and ancestries," they concluded.
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